TUCSON, Ariz. — More than two and a half months after 84-year-old Nancy Guthrie vanished from her Catalina Foothills home, authorities and medical experts continue to express grave concerns about her fragile health, with no confirmed sightings or proof she remains alive despite ongoing FBI DNA analysis and new ransom claims.

Guthrie, the mother of NBC’s “Today” co-anchor Savannah Guthrie, was last seen Jan. 31, 2026, after a family dinner. She was reported missing the next morning when she failed to join friends for an online church service. Investigators believe she was abducted in the early morning hours of Feb. 1, citing surveillance footage of a masked, armed individual tampering with her doorbell camera around 1:47 a.m. and data showing her pacemaker disconnecting from her phone at approximately 2:30 a.m., indicating the device moved out of range.

Drops of blood confirmed to match Guthrie’s DNA were found on her front porch, though the scene showed relatively little disarray, leading some experts to suggest something went wrong quickly during the incident. No signs of a major struggle were reported, but the presence of blood and the abrupt pacemaker disconnection heightened immediate worries about injury and her underlying medical conditions.

From the outset, law enforcement has emphasized Guthrie’s precarious health as a critical factor. The 84-year-old relied on daily medications for high blood pressure and other cardiac issues, and she had a pacemaker. Family members and authorities noted she was not in robust condition, with limited mobility due to a bad back and other age-related ailments. Doctors warned that missing even a short period of her prescribed regimen could prove life-threatening, raising risks of heart attack, stroke, dehydration or other complications exacerbated by stress and possible captivity.

Pima County Sheriff Chris Nanos stated early in the investigation that Guthrie was “sharp as a tack” mentally but physically vulnerable, with her life potentially at risk without prompt access to medication. A doctor appearing on media outlets highlighted how abduction stress on an elderly person with cardiac problems could trigger fatal events, noting adults over 60 often feel heightened terror and vulnerability in such situations.

As weeks turned into months, those concerns have only deepened. By early April, former detectives and criminal profilers suggested kidnappers may have fatally underestimated Guthrie’s fragility. One Indiana detective told NewsNation that the abductors likely assumed they could hold an elderly woman for ransom briefly before releasing her, but her health may have deteriorated rapidly under duress, possibly leading to a medical event or the decision to dispose of her body when she was “no longer of value.”

Forensic nurse and criminal profiler Ann Burgess theorized that “something went very wrong” inside the home, pointing to the limited blood evidence and wondering about its source and spread. Experts have speculated the perpetrators might have planned a quick operation but encountered complications due to Guthrie’s condition, shifting from ransom to potential cover-up.

The investigation has yielded incremental developments but no breakthrough in locating Guthrie or identifying suspects. The FBI recently received and is analyzing a mixed DNA sample recovered from her home, including results from a hair sample, using advanced new technology in hopes of generating leads. Sources familiar with the probe described the DNA as potentially critical, though results have not yet been publicly linked to any individual.

Multiple ransom notes have surfaced, some sent to TMZ demanding cryptocurrency payments. Earlier demands carried deadlines that passed without resolution. In recent days, additional letters claimed knowledge of Guthrie’s body location and the kidnapper’s identity, but their authenticity remains unverified and authorities have not confirmed any payments or credible breakthroughs from them.

No suspects have been named publicly more than 75 days into the case. Surveillance video, DNA from gloves or other items, and neighborhood canvassing have not produced arrests. Some experts suggest the perpetrator could be someone Guthrie knew or who had scouted the home weeks earlier, based on timeline details shared by the sheriff.

Savannah Guthrie has stepped away from “Today” show duties at times amid the anguish, with family maintaining a low public profile while cooperating fully with investigators. Friends described Nancy as mentally sharp, socially active — she played mahjong, read books and celebrated her birthday shortly before disappearing — despite physical limitations that made even walking to the mailbox challenging on difficult days.

Health experts consulted on the case have painted a bleak picture for prolonged captivity. Without blood pressure medication and cardiac support, an 84-year-old with a pacemaker faces elevated risks of arrhythmia, hypertension crises or strokes. Stress from abduction could compound these, potentially causing a fatal cardiac event within days or weeks. Dehydration, lack of proper nutrition or injury from the initial incident would accelerate decline.

Some analysts note that dropping ransom amounts in later communications might signal desperation on the perpetrator’s side — or indicate that the victim’s health had already failed, reducing leverage. Odds of a safe rescue after this length of time for an elderly person with medical needs are estimated low by some observers, though officials continue to urge the public for tips and treat the case as an active abduction.

The broader context adds layers of complexity. The case has drawn national attention due to Savannah Guthrie’s prominence, sparking a media circus with amateur sleuths and vloggers trespassing in the neighborhood, prompting sheriff’s warnings. It also highlights vulnerabilities for elderly residents in upscale areas, where targeted crimes can exploit perceived isolation.

Pima County investigators, working with the FBI, maintain a team of about two dozen on the case. Recent activity included renewed neighborhood presence, though residents expressed frustration over disruptions. Advanced DNA testing represents the latest hope for a genetic match that could identify a suspect or confirm connections.

Family and friends have expressed profound worry, not only about Nancy’s safety but specifically her ability to survive without medical intervention. In early statements, they stressed she could not go long without her prescriptions. The pacemaker disconnection early in the timeline suggested rapid removal from her familiar environment, cutting off monitoring and support.

As the search enters its third month, authorities continue to appeal for information. Tips can be directed to the Pima County Sheriff’s Department or the FBI. While some profilers speculate the worst — that health complications led to disposal of remains — officials have not declared her deceased and emphasize every lead is pursued with urgency.

Medical realities for someone in Guthrie’s position make time the enemy. Experts repeatedly note that even if initially uninjured beyond minor blood loss, the combination of age, cardiac history, medication dependence and abduction trauma creates a narrow window for survival without intervention. Stories of other missing elderly individuals sometimes end with survival due to resilience or quick recovery, but those cases rarely involve suspected violent abduction.

The Guthrie family’s private pain has played out publicly through Savannah’s occasional on-air emotions and stepped-away moments, humanizing the ordeal for viewers. Nancy was portrayed as a devoted mother and grandmother with a quiet faith, mischievous humor and strong community ties in the Tucson area.

Whether new DNA analysis yields a suspect, or further ransom communications provide actionable intelligence, the health concerns remain paramount. Detectives fear the kidnappers’ miscalculation about an elderly woman’s endurance may have turned a planned extortion into tragedy. Until concrete evidence emerges — a safe return, recovery of remains or arrest — the uncertainty compounds the anguish for loved ones already racing against her medical vulnerabilities.

The case serves as a sobering reminder of how quickly an elderly person’s health can deteriorate under extreme circumstances. For now, Nancy Guthrie’s condition — wherever she may be — continues to drive the investigation’s sense of urgency, even as weeks stretch into months with more questions than answers.

NEW YORK — AXT Inc. shares exploded higher Thursday, surging nearly 30% to close at $81.78 after a volatile session that saw the stock swing from $59.30 to an intraday high of $82.19, as momentum traders piled into the compound semiconductor maker amid broader excitement over artificial intelligence infrastructure demand.

The dramatic one-day gain on April 16, 2026, came on heavy volume exceeding 16.7 million shares, more than 10 times the average, pushing the company’s market capitalization well above $3 billion despite trailing 12-month revenues of roughly $88 million and ongoing net losses. The rally extended a stunning run that has seen the stock climb from around $1 in early 2025 to current levels, delivering returns exceeding 2,800% for early holders.

Yet the surge has left many Wall Street analysts shaking their heads. Consensus price targets from five to 11 covering analysts hover between $14.75 and $35.60, implying potential downside of 55% to 82% from Thursday’s close. Ratings remain mixed, with a lean toward “Hold” overall — two Buy, two Hold and one Sell in recent tallies — even as some longer-term forecasts see revenue growth ahead.

AXT, based in Fremont, California, specializes in indium phosphide (InP), gallium arsenide (GaAs) and germanium substrates used in high-speed optical components, data center connectivity, wireless communications and other advanced applications. Indium phosphide has emerged as a critical material for optical interconnects that help alleviate bandwidth bottlenecks in AI training clusters and hyperscale data centers.

Management has highlighted strong underlying demand, particularly for InP wafers tied to the AI build-out. In comments accompanying delayed fourth-quarter 2025 results, Chief Executive Morris Young noted progress on export permits from China and expressed confidence in sequential revenue growth for the first quarter of 2026. The company plans to more than double its InP production capacity by the end of 2026, with potential for another doubling in 2027 to meet projected order growth.

First-quarter 2026 earnings are scheduled for release after the market close on April 30, with analysts expecting revenue around $26 million and a loss per share of about $0.05. Full-year 2026 revenue estimates range from roughly $100 million to $125 million in some models, reflecting optimism about recovering shipments and capacity expansion, though earlier guidance had been tempered by export control delays in late 2025.

The bullish case rests on AXT’s positioning in a multi-year growth cycle for optical communications. As AI models scale, the need for faster, more efficient data movement between servers drives demand for InP-based lasers and detectors. Company executives have pointed to broadening customer relationships, including with tier-one optical players previously underserved, and a robust backlog once permitting issues ease.

Yet skeptics argue the stock’s valuation has detached from fundamentals. At current levels, AXT trades at elevated multiples — roughly 20-30 times forward sales in some calculations — while still posting losses. Trailing earnings remain negative, and the company carried a net loss of $21.3 million on $88.3 million in revenue for fiscal 2025. Insider selling totaling millions of dollars in recent months has added to concerns about whether executives view the run-up as a selling opportunity.

Geopolitical risks loom large. A significant portion of AXT’s manufacturing occurs in China, subjecting indium phosphide shipments to export license approvals by Chinese authorities. Delays in permits contributed to a fourth-quarter 2025 revenue miss, and any future tightening of U.S.-China technology restrictions or retaliatory measures could disrupt supply chains or customer orders.

Analysts at firms like B. Riley have expressed incremental caution on the InP supply chain, while others note that competitors or alternative technologies could eventually ease the current bottleneck. Some models peg fair value closer to $28, suggesting the stock is overvalued by more than 50% even if growth materializes.

Technical analysts observe that the rapid ascent has left the shares extremely extended. The stock has broken out dramatically but now sits well above most moving averages, raising the risk of a sharp pullback if momentum fades or if the upcoming earnings disappoint. Short interest and options activity reflect heightened speculation, with traders betting on continued volatility.

For investors considering a position in 2026, the debate centers on timing and risk tolerance. Bulls point to the transformative potential of AI-driven demand and AXT’s capacity ramp as reasons to hold or add on dips, arguing that current prices bake in optimistic scenarios for 2027 and beyond when revenue could approach or exceed $200 million in some projections. Capacity expansion, if executed smoothly, could support higher margins and eventual profitability.

Bears counter that the market has gotten ahead of itself. With analyst targets clustered far below current trading levels and persistent losses, the risk-reward skews negative for new buyers at these prices. Those who rode the rally from single digits may consider taking profits, especially ahead of earnings that could serve as a reality check on near-term execution.

Broader semiconductor sector sentiment remains supportive, with AI spending by hyperscalers like Microsoft, Google and Amazon continuing to fuel optimism. However, AXT’s small size, customer concentration risks and exposure to policy shifts differentiate it from larger, more diversified chip players.

Longer-term forecasts vary widely. Some optimistic models see the stock reaching $85 or higher within 12 months under ideal conditions, while more conservative estimates warn of a return toward the $20-$30 range if growth disappoints or macro headwinds intensify. Revenue visibility improves in the second half of 2026 if capacity comes online and permits flow more freely, but investors should prepare for quarterly lumpiness.

Dividend investors will find little appeal, as AXT does not currently pay one and focuses resources on growth and operations. The balance sheet includes some cash but also reflects investments in expansion.

Market participants should monitor upcoming developments closely: the April 30 earnings report and conference call, any updates on China export permits, progress on capacity additions, and shifts in AI capital expenditure plans by big tech. Broader trade tensions or interest rate moves could also sway sentiment.

In summary, AXT Inc. offers exposure to a compelling secular theme in AI infrastructure but carries substantial valuation, execution and geopolitical risks. The explosive move to $81.78 in April 2026 has rewarded patient holders yet left new entrants facing a high bar for justification. Conservative investors may prefer to wait for a pullback or clearer evidence of sustained profitability, while aggressive growth-oriented traders might view volatility as opportunity — albeit with tight risk management.

Whether the stock ultimately justifies its current premium will depend on AXT’s ability to convert hype into consistent revenue growth and positive earnings in the quarters ahead. For now, the market appears split between euphoria over AI tailwinds and skepticism about stretched fundamentals.

LONDON — The FTSE 100 index closed at 10,589.99 on Thursday, rising 30.41 points or 0.29% in a modest but steady rebound that lifted London’s blue-chip benchmark after a softer session the day before.

Trading volume reached approximately 648 million shares as the index swung between a low of 10,555.53 and a high of 10,645.90 during the session. The gain came amid mixed signals from global markets, with investors weighing fresh U.K. economic data, corporate earnings and ongoing geopolitical developments in the Middle East.

The FTSE 100 now sits comfortably above the psychologically important 10,500 level but remains below its all-time high of 10,934.94 hit in February 2026. Year to date, the index has posted solid gains of around 3.9%, while it has surged nearly 28% over the past 12 months, reflecting resilience despite periodic volatility.

Analysts pointed to a combination of factors supporting Thursday’s advance. A surprise uptick in U.K. GDP figures provided a welcome boost, easing some concerns about economic slowdown. Retail heavyweight Tesco and testing services firm Intertek were among the notable risers, helping to propel the index higher. Entain also advanced on positive momentum in the gaming sector.

Banking stocks offered mixed performance, with some lenders limiting broader gains while others benefited from expectations of stable interest rates. Healthcare names weighed on the index earlier in the week but showed signs of stabilization as traders digested recent results.

The broader FTSE 250, which includes more domestically focused mid-cap companies, outperformed with a 0.5% rise to 22,779.50, adding 113.91 points. The AIM All-Share index edged up 0.2% to 797.86.

Market participants remain cautious about developments between the U.S. and Iran, with peace talks providing some relief from earlier tensions that had weighed on energy and defense stocks. Oil prices hovered near recent levels, supporting shares in BP and Shell, two of the FTSE 100’s heaviest constituents.

Commodity-related stocks saw varied movement. Miners and energy firms, which often drive FTSE performance due to their significant weighting, contributed positively as metals and crude stabilized. Glencore and BAE Systems have been standout performers earlier in 2026, though some of that momentum moderated in recent sessions.

Economists noted that the U.K. economy has shown surprising strength in early 2026, with GDP figures helping to counter worries about inflation and consumer spending. However, challenges persist, including elevated energy costs affecting farmers and households, as well as uncertainty around global trade dynamics.

The FTSE 100’s dividend yield stands around 3.1%, making it attractive for income-seeking investors compared with many international peers. With a market capitalization exceeding £2.4 trillion, the index continues to represent a broad cross-section of the British economy, from multinational giants to household names.

Looking ahead, traders will watch for upcoming corporate updates and inflation data that could influence Bank of England policy expectations. Some forecasts suggest the index could test the 10,700-10,900 range if positive momentum builds, while support lies near 10,400 and the 200-day moving average.

Over the longer term, the FTSE 100 has delivered average annual returns of roughly 8% over the past decade when including dividends, though performance has lagged some technology-heavy indices like the U.S. S&P 500. Its heavy tilt toward value sectors such as financials, energy and materials has provided a buffer during periods of tech volatility.

Recent quarterly performance highlighted both winners and laggards within the index. Insurance and financial names like Beazley and Schroders posted strong gains exceeding 40% in the first three months of 2026, while homebuilders such as Barratt Redrow and travel stocks like easyJet faced steeper declines amid higher borrowing costs and shifting consumer behavior.

International investors have shown renewed interest in U.K. equities, drawn by relatively attractive valuations and a weaker pound in prior periods. Sterling’s movements against the dollar and euro will continue to play a role in multinational earnings translations.

Technical analysts observe that the index has been trading within a broader uptrend since breaking above 10,000 earlier in 2026. Short-term resistance appears near recent highs around 10,645, with further upside potentially capped until clearer catalysts emerge.

The rebound on Thursday contrasted with Wednesday’s 0.47% decline, when healthcare and consumer stocks faced pressure. That session saw the index close at 10,559.58 before recovering ground.

Broader European markets ended the day with modest moves, reflecting a wait-and-see approach among investors. The DAX in Germany and CAC 40 in France showed limited net changes as regional economic indicators came into focus.

U.S. markets, trading later in the global cycle, provided additional context with the Dow Jones Industrial Average and S&P 500 posting fractional gains amid their own corporate earnings season.

For U.K. retirees and pension funds, the FTSE 100 remains a core holding, offering exposure to stable dividend payers. However, critics have long argued that the index’s composition could benefit from greater technology and growth sector representation to match the dynamism seen elsewhere.

Capcom’s video game adaptations and other entertainment crossovers occasionally capture headlines, but Thursday’s focus stayed firmly on traditional market drivers. No major mergers or regulatory announcements moved the needle significantly during the session.

Volume and volatility remained in line with recent averages, suggesting no panic or euphoria in the market. The VIX equivalent for U.K. stocks stayed subdued, indicating calm investor sentiment.

As trading resumes Friday, attention will turn to any overnight developments in geopolitics or fresh U.K. data releases. Many strategists maintain a constructive outlook for the index through the remainder of 2026, citing undervaluation relative to earnings potential and supportive monetary policy.

The FTSE 100’s journey above 10,000 earlier this year marked a milestone, building on strong 2025 performance. While it has pulled back from February peaks, the current level around 10,590 reflects underlying confidence in British business resilience.

Investors seeking exposure can access the index through trackers, ETFs or individual blue-chip shares. With a price-to-earnings ratio that remains competitive globally, the FTSE continues to appeal to those hunting value in a high-valuation world.

In summary, Thursday’s 0.29% advance to 10,589.99 underscored the FTSE 100’s ability to find support and push higher amid a complex backdrop. Whether this marks the start of renewed momentum or a temporary pause will depend on incoming economic signals and corporate health.

The index is expected to open Friday near current levels, with analysts monitoring for any breakout above recent intraday highs.

Plans led by Bankfoot APAM on behalf of the Greater Manchester Pension Fund

Stalybridge train station will soon be surrounded by 102 new homes following planning approval.

The transport hub can expect to see a mixture of three-storey town houses and apartment blocks built on unused land on its doorstep. Approval means the area will see Harrop Street car park, industrial buildings off Water Street and the land historically occupied by Rassbottom Mill will be flattened in order to facilitate 44 townhouses and 58 apartments.

The plans tabled by Bankfoot APAM, on behalf of the Greater Manchester Pension Fund, would all be available for affordable rates (up to 80 per cent of market value).

Potential new residents in the complex would also benefit from ‘quality’ private spaces, including front and rear gardens; roof terraces; and access to the new riverside public realm. Some 56 car parking spaces, 120 cycle storage spots and tree plantings are also included in the plans.

This scheme would form part of the first residential phase of an overhaul of Stalybridge’s western edge. This section of the town has been targeted under a £11.1m scheme for new housing, improved roads, public realm upgrades, a new multi-storey car park and a pedestrian footbridge.

The idea behind this is to deliver regeneration of the town centre, attract further investment, and deliver vital new housing. The proposed new multi-level car park would replace existing surface level car parking lost when the council sold off land to facilitate the development. The footbridge across the River Tame would then help improve access to the new residential quarter of the town.

Planning papers read: “Stalybridge was once a leader in the cotton manufacturing industry of Victorian Britain, the town has been shaped around its industrial heritage, utilising its natural assets for industrial growth.

“Our proposals look to support Stalybridge’s connection to the river that once shaped the town’s growth. An ambition to create a new vibrant residential-led neighbourhood for the town; incorporating good quality public realm, high quality design and delivering uses that encourage engagement and inclusion with the local community.”

The planning panel, chaired by Coun David Mills, unanimously approved the scheme at their latest meeting in Guardsman Tony Downes House in Droylsden.

To find all the planning applications, traffic diversions, road layout changes, alcohol licence applications and more in your community, visit the Public Notices Portal.

Zambrero is looking to open outlets in larger towns and cities such as Bristol, Bath, Exeter and Plymouth

An Australian-owned food chain that sells Mexican-inspired cuisine is looking to open a host of outlets across the West of England in the next three years.

Zambrero has appointed three development agents – James Fleck, Michelle Jelfs and Sarah Preston – to spearhead the expansion across Bristol, Dorset, Somerset, Devon and Cornwall.

The trio will be responsible for franchise partner recruitment in the region, with plans to open at least nine restaurants, creating around 135 jobs, including full and part-time roles.

Development will initially focus on larger towns and cities within the region, including Bath, Bournemouth, Bristol, Exeter, Plymouth, Poole, Taunton and Weston-super-Mare.

Initial efforts will be made to secure locations in high footfall areas on high streets, large shopping centres – such as Cabot Circus and Cribbs Causeway in Bristol – retail parks and roadside destinations, according to the company.

The development agents will also be responsible for expansion in the West Midlands, with plans to open at least 12 restaurants via franchise partners in Birmingham, Coventry, Dudley, Solihull, Walsall, Leamington Spa and Worcester over the next three years.

The team will also assist with location acquisition, operational support, brand integrity, regional marketing activation and business strategy, Zambrero said.

“We’re incredibly excited to join the Zam Fam at such a pivotal stage in the brand’s growth,” said Mr Fleck. “Having worked within the hospitality industry for many years, it is clear to me that Zambrero truly stands out – from its fresh, high-quality Mexican food and modern restaurant design, to its positive culture and clear sense of purpose.”

The news comes as the Mexican restaurant group’s looks to open 100 restaurants in the UK by 2030 through strategic franchise partnerships.

Since its 2021 launch, Zambrero now has 14 restaurants across the UK, located in London, Manchester, Birmingham, Reading, Essex and Glasgow.

“We’re actively seeking passionate, committed and like-minded franchise partners to join us in expanding Zambrero across the South West,” added Mr Fleck.

“For ambitious entrepreneurs ready to lead the way in the South West, now is the time to join us on this exciting journey.”

Zambrero has grown into a global brand through its successful franchise programmes, and now has more than 350 restaurants in Australia, Ireland, New Zealand, the UK and the US. It is also the largest Mexican restaurant franchise in Australia and Ireland.