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Moderna (MRNA) Stock Slips Despite Beating Q4 Revenue and Earnings Estimates

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MRNA Stock Card

TLDR

  • Moderna reported Q4 revenue of $678 million, beating Wall Street estimates of $626.1 million, driven by COVID-19 vaccine sales
  • The company posted a quarterly loss of $2.11 per share, narrower than the $2.54 per share loss analysts expected
  • Moderna reiterated its 2026 revenue growth target of 10% and expects 50% of sales from U.S. markets and 50% from international
  • FDA refused to review Moderna’s flu vaccine application this week, citing trial design flaws, despite internal staff reviewers supporting the review
  • Moderna stock slipped 0.3% in premarket trading Friday despite beating earnings, after rising 36% year-to-date through Thursday

Moderna shares dipped 0.3% in premarket trading Friday even after the biotech company delivered quarterly results that topped Wall Street expectations. The mixed reaction highlights investor concerns about the company’s path forward after a rough week.

The Cambridge-based vaccine maker reported fourth-quarter revenue of $678 million. That beat analyst estimates of $626.1 million.

Full-year 2025 sales reached $1.94 billion, surpassing the $1.89 billion consensus estimate. COVID-19 vaccine sales drove the better-than-expected performance.


MRNA Stock Card
Moderna, Inc., MRNA

Moderna posted a quarterly loss of $2.11 per share. Analysts had projected a steeper loss of $2.54 per share. The latest loss was narrower than the $2.91 per share loss recorded in the same quarter last year.

CEO Stéphane Bancel said the company entered the year “with strong momentum despite the continued challenging environment in the U.S.” The company reaffirmed its expectation for 10% revenue growth in 2026 compared to 2025.

Wall Street currently expects revenue growth of about 6% for the year. Moderna forecast research and development expenses of roughly $3 billion for 2026, matching analyst estimates.

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FDA Setback Casts Shadow

The earnings beat came days after a setback with regulators. The FDA refused Tuesday to review Moderna’s seasonal flu vaccine application.

FDA vaccine chief Vinay Prasad said the company should have compared its vaccine to standard high-dose flu shots for older adults. Moderna ran its trial using regular-dose comparisons, which the company says FDA approved 18 months ago.

Internal FDA staff reviewers had supported moving forward with the review. Prasad overruled them, according to a Wednesday report from Stat.

Moderna criticized the decision and said it was awaiting further guidance on refiling. The company has been counting on its flu vaccine and a future COVID-flu combination shot to drive future growth.

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Looking Ahead to 2026

The company expects about 50% of 2026 sales to come from U.S. markets. International markets will account for the remaining half.

Bancel said Moderna expects to meet its 2026 targets through expansion of its next-generation COVID vaccine. Strategic partnerships in international markets will also play a role.

Shares had climbed 36% year-to-date through Thursday’s close. Positive Phase 2b trial results for an intismeran autogene vaccine used in melanoma treatment drove much of the rally.

The company continues working on newer products to offset declining COVID vaccine demand. Sales have struggled since the pandemic windfall years when demand for COVID shots collapsed.

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Moderna’s full-year 2025 revenue of $1.94 billion came in above the $1.89 billion analyst consensus, while the company maintains its 10% revenue growth target for 2026.

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Ethereum Struggles Below $2K as Derivatives Markets Shed 80M ETH in Open Interest

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quicktake-image

TLDR:

  • Ethereum rejected at $2.1K resistance after breaking support, confirming bearish structure remains intact 
  • Open interest declined 80M+ ETH across exchanges in 30 days, with Binance leading at 40M reduction 
  • Technical framework requires sustained reclaim of $2.1K-$2.15K range to shift bias back to bullish  
  • Derivatives market cleanup reduces leverage risk and may establish foundation for price stability

 

Ethereum continues to trade below critical support levels while derivatives markets show widespread deleveraging.

The asset sits at $1,958.53 as of this writing after failing to hold the $2.1k threshold. Meanwhile, open interest across major exchanges has contracted by more than 80 million ETH over the past month.

This dual pressure from spot price weakness and futures market retreat signals a period of market recalibration.

Technical Breakdown Points to Further Downside Risk

Ethereum’s price structure has followed a textbook pattern of support failure and failed reclaim attempts. The rising trendline near $2.8k marked the initial breakpoint in this sequence. Once that level gave way, the asset moved swiftly toward $2.1k support.

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Market participants initially viewed the $2.1k zone as a potential floor for consolidation. However, that expectation proved premature as the level failed to contain selling pressure.

The subsequent drop carried ETH down to $1.7k before any meaningful bounce materialized.

Analyst Dami-Defi noted on X that the asset “bounced just enough to suck in hope” before retesting the broken $2.1k support.

That retest resulted in a clear rejection, confirming the zone had flipped from support to resistance. This behavior typically indicates continued weakness rather than bullish recovery.

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The current technical framework suggests limited upside potential while ETH trades below $2.1k. A sustained reclaim of the $2.1k-$2.15k range would be required to shift the bias.

Until such a development occurs, counter-trend rallies represent selling opportunities rather than the start of new uptrends.

Futures Market Contraction Reflects Cautious Positioning

Cryptoquant analyst Arab Chain reported that derivatives markets have undergone substantial position reduction across multiple platforms.

Binance recorded the largest decline with approximately 40 million ETH in open interest exiting over 30 days. Gate.io followed with more than 20 million ETH in reduced exposure.

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Additional platforms showed similar trends with OKX declining by 6.8 million ETH and Bybit by 8.5 million ETH. These four venues alone account for roughly 75 million ETH in reduced open interest.

quicktake-image

Source: Cryptoquant

When smaller exchanges are included, the total contraction exceeds 80 million ETH across the ecosystem.

This pattern indicates traders are closing positions rather than establishing new leveraged bets. The move reflects either profit-taking after extended positioning or risk reduction in response to volatile conditions.

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High-leverage participants appear particularly active in unwinding exposure during this phase.

The derivatives market reset may ultimately create healthier conditions for future price discovery. Reduced leverage decreases the risk of cascading liquidations that amplify volatility.

This cleanup process often precedes periods of greater stability and can establish a firmer foundation for subsequent moves.

 

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BlackRock Raises BitMine Immersion Technologies Stake to Over 9 Million Shares

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21Shares Introduces JitoSOL ETP to Offer Staking Rewards via Solana

TLDR:

  • BlackRock increased BitMine holdings to 9,049,912 shares, up 165.6% from last quarter
  • The total position is valued at roughly $246 million according to the latest 13F filing
  • BitMine controls about 4.3 million ETH, or nearly 3.5% of Ethereum’s circulating supply
  • Institutional investors continue adding exposure through crypto-linked public equities

 

BlackRock increased its ownership in BitMine Immersion Technologies during the latest reporting period. A new regulatory filing shows the asset manager raised its stake to 9,049,912 shares, marking a 165.6% quarterly jump and valuing the position at roughly $246 million.

Institutional Allocation Grows

The updated position appeared in BlackRock’s most recent 13F disclosure filed with U.S. regulators. These filings list equity holdings managed across the firm’s broad investment portfolios.

The document shows a sharp rise from the prior quarter’s reported share count.The latest total now exceeds nine million shares of BitMine common stock.

The company trades publicly under the ticker BMNR. It operates immersion-based mining facilities and manages digital assets on its balance sheet.

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Shortly after the filing surfaced, crypto-focused accounts shared the figures on social media. One widely circulated post noted that BlackRock had loaded up on BitMine shares.

The message cited the same increase and valuation metrics from the official filing. It framed the purchase as another move by institutions toward crypto-related equities.

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BlackRock oversees trillions of dollars across global markets and sectors. Movements of this scale often draw attention from traders and analysts.

Ethereum Treasury Strategy

BitMine’s business model combines mining infrastructure with long-term cryptocurrency holdings. Its treasury includes approximately 4.3 million ETH accumulated through operations and reserves.

That amount represents around 3.5% of Ethereum’s circulating supply. The figure places the company among the larger known corporate holders of the asset.

Holding such reserves ties company performance closely to digital asset prices. Changes in Ethereum’s value can influence both revenue expectations and balance sheet strength.

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BlackRock’s expanded position increases institutional exposure to that structure. It links traditional capital management with companies directly tied to blockchain assets.

Quarterly disclosures offer measurable data for tracking these allocations. They provide concrete numbers rather than market rumors or short-term speculation.

The latest filing presents a clear snapshot of BlackRock’s current commitment. With over nine million shares, BitMine becomes a larger piece of its public equity holdings.

The increase arrives as crypto-focused strategies continue attracting institutional capital. Public filings now serve as a key source for monitoring that steady accumulation.

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BlackRock Enters DeFi Via UniSwap, Bitcoin Stages Modest Recovery

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BlackRock Enters DeFi Via UniSwap, Bitcoin Stages Modest Recovery

BlackRock made its first formal move into decentralized finance this week, listing its tokenized Treasury fund on Uniswap, with Bitcoin and Ether staging only modest rebounds amid heavy ETF outflows.

Bitcoin (BTC) and Ether (ETH) each rose about 2.5% during the past week but were unable to cross key psychological levels due to mixed exchange-traded fund (ETF) flows and crypto investor sentiment sinking to record lows.

Bitcoin ETFs started the week with two consecutive days of inflows, but they quickly reversed with $276 million in outflows on Wednesday and $410 million on Thursday.

Ether ETFs saw similar flows, with two modest days of inflows, followed by $129 million in outflows on Wednesday and $113 million on Thursday, according to Farside Investors data.

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In a silver lining to the correction, Bitcoin’s sharp drawdown to $59,930 may have marked a critical “halfway point” in the current bear market, as markets are now sitting at a critical inflection point that will determine the relevance of the four-year cycle theory, according to Kaiko Research.

Despite sliding crypto valuations, large institutions continue exploring cryptocurrency adoption, including the world’s largest asset manager, BlackRock, which announced its first foray into decentralized finance (DeFi) on Wednesday.

Bitcoin ETF inflows, in USD million. Source: Farside Investors

BlackRock enters DeFi, taps Uniswap for institutional token trading

Asset management giant BlackRock is making its first formal move into decentralized finance by bringing its tokenized US Treasury fund to Uniswap, marking a milestone moment for institutional adoption of DeFi.

According to a Wednesday announcement, BlackRock’s USD Institutional Digital Liquidity Fund (BUIDL) will be listed on the Uniswap decentralized exchange, allowing institutional investors to buy and sell the tokenized security. 

As part of the arrangement, BlackRock is also purchasing an undisclosed amount of Uniswap’s native governance token, UNI, the announcement said.

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The collaboration is being facilitated by tokenization company Securitize, which partnered with the world’s biggest asset manager on the launch of BUIDL.

According to Fortune, trading will initially be limited to a select group of eligible institutional investors and market makers before expanding more broadly.

“For the first time, institutions and whitelisted investors can access technology from a leader in the decentralized finance space to trade tokenized real-world assets like BUIDL with self-custody,” said Securitize CEO Carlos Domingo.

Source: Securitize

BUIDL is the biggest tokenized money market fund, with more than $2.18 billion in total assets, according to data compiled by RWA.xyz. The fund is issued across multiple blockchains, including Ethereum, Solana, BNB Chain, Aptos and Avalanche. 

In December, BUIDL reached a key milestone, surpassing $100 million in cumulative distributions from its Treasury holdings.

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BlackRock’s BUIDL metrics. Source: RWA.xyz

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Trump family’s WLFI plans FX and remittance platform: Report

World Liberty Financial (WLFI), a decentralized finance (DeFi) platform backed by the family of US President Donald Trump, announced on Thursday that it will launch foreign currency exchange (FX) and remittance services for its users.

The planned foreign exchange and remittance platform, called World Swap, seeks to challenge traditional remittance and FX service providers with lower fees and a simplified user interface, according to Reuters.

Daily global FX trading volume surpassed $9.6 trillion in April 2025, according to a report from the Bank for International Settlements (BIS), and the personal remittances market topped $892 billion in annual volume in 2024, according to data from the World Bank.

Business, Forex, Donald Trump, DeFi
Annual remittances volume from 1970 to 2024. Source: World Bank

No exact timeline was given for the rollout. Cointelegraph reached out to World Liberty Financial but did not receive a response by the time of publication.

The expansion into FX and remittances follows WLFI’s application for a national trust bank charter in January and the launch of World Liberty Markets, a lending platform, as WLFI continues to grow while attracting scrutiny from Democratic lawmakers in the US.

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Uniswap scores early win as US judge dismisses Bancor patent suit

A New York federal judge dismissed a patent infringement lawsuit brought by Bancor-affiliated entities against Uniswap, ruling that the asserted patents claim abstract ideas and are not eligible for protection under US patent law.

In a memorandum opinion and order on Tuesday, Judge John G. Koeltl of the US District Court for the Southern District of New York granted the defendant’s motion to dismiss the complaint filed by Bprotocol Foundation and LocalCoin Ltd. against Universal Navigation Inc. and the Uniswap Foundation. 

The court found that the patents are directed to the abstract idea of calculating crypto exchange rates and therefore fail the two-step test for patent eligibility established by the US Supreme Court. 

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The ruling marks a procedural win for Uniswap, but it is not final. The case was dismissed without prejudice, giving the plaintiffs 21 days to file an amended complaint. If no amended complaint is filed, the dismissal will convert to one with prejudice.

Shortly after the ruling, Uniswap founder Hayden Adams wrote on X, “A lawyer just told me we won.”

“Uniswap Labs has always been proud to build in public — it’s a core value of DeFi,” a Uniswap Labs spokesperson told Cointelegraph. “We’re pleased that the court recognized that this lawsuit was meritless.”

Law, Patents, United States, Bancor, DeFi, Uniswap, DEX
Source: Hayden Adams

Cointelegraph reached out to representatives of Bprotocol Foundation for comment but had not received a response by publication.

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Binance completes $1 billion Bitcoin conversion for SAFU emergency fund

Binance completed the $1 billion Bitcoin conversion for its emergency fund, committing to holding Bitcoin as its core reserve asset.

Binance purchased another $304 million worth of Bitcoin (BTC) on Thursday, completing the conversion of $1 billion in Bitcoin for its Secure Asset Fund for Users (SAFU) wallet, according to Arkham data.

The fund now holds 15,000 Bitcoin, worth over $1 billion, acquired at an average aggregate cost basis of $67,000 per coin, Binance said in a Thursday X post.

 “With SAFU Fund now fully in Bitcoin, we reinforce our belief in BTC as the premier long-term reserve asset.”

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The last tranche of BTC came three days after Binance’s previous $300 million acquisition on Monday.

Binance SAFU Fund wallet. Source: Arkham

The exchange first announced it would convert its $1 billion user protection fund into Bitcoin on Jan. 30, initially pledging a 30-day window for the acquisitions, which were completed in less than two weeks.

The exchange said it would rebalance the fund if volatility pushes its value below $800 million.

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Vitalik draws line between “real DeFi” and centralized yield stablecoins

Ethereum co-founder Vitalik Buterin drew a clear boundary around what he considers “real” decentralized finance (DeFi), pushing back against yield-driven stablecoin strategies that he says fail to meaningfully transform risk. 

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In a discussion on X, Buterin said that DeFi derives its value from changing how risk is allocated and managed, not simply from generating yield on centralized assets. 

Buterin’s comments come amid renewed scrutiny over DeFi’s dominant use cases, particularly in lending markets built around fiat-backed stablecoins like USDC (USDC). 

While he did not name specific protocols, Buterin took aim at what he described as “USDC yield” products, saying they depend heavily on centralized issuers while offering little reduction in issuer or counterparty risk.

Source: Vitalik Buterin

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DeFi market overview

According to data from Cointelegraph Markets Pro and TradingView, most of the 100 largest cryptocurrencies by market capitalization ended the week in the green.

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The Pippin (PIPPIN) token rose 195% as the week’s biggest gainer in the top 100, followed by the Humanity Protocol (H) token, up 57% during the past week.

Total value locked in DeFi. Source: DefiLlama

Thanks for reading our summary of this week’s most impactful DeFi developments. Join us next Friday for more stories, insights and education regarding this dynamically advancing space.