Tech
What’s The Difference Between American And European Traffic Lights?
One of the most important safety advancements to happen to the world of wheeled transport, is the traffic light. If you have a driver’s license, you already know how it works; if the light is red, it means stop, and when the light turns green, it means go. In the United States, when the green light is up, the amber light comes on letting you know it’s time to slow down before it turns red. In Europe, that happens as well, but also, before they turn green, European traffic signals will enable both the red and amber light at the same time.
The amber and red lights illuminating simultaneously indicates that you should prepare to set off. That makes sense and considering Europeans use manual transmissions a lot more, it gives you just the right amount of time to push the clutch in and shift into first.
In some European countries, the green signal also flashes a couple of times to let you know that it’s about to turn red. In the U.S., the amber light does not come on before the change from red to green.
Other key differences between European and American traffic signals
European traffic signals have a few other differences compared to American traffic signals. The colors are the same, and the colors on traffic lights have a pretty interesting origin story. One of the differences is the amber light flashing on its own; American traffic lights have this as well, but it’s usually to warn of pedestrians or other road hazards that are coming up, or they indicate that you should yield to oncoming traffic and pedestrians if you’re making a turn.
In Europe, a flashing yellow traffic light often means that the signal has been disabled, and that you should pay attention to the road sign directly above the traffic light (which could be either right of way or yield). Traffic lights are always disabled when police officers are guiding traffic, and at that point, their signals take precedent over everything else.
What’s more, European traffic signals are also designed around pedestrians and cyclists, since a lot of cycle lanes are often directly next to the road. Speaking of pedestrians, whereas most traffic lights in America will display Walk and Don’t Walk in big capital letters, European traffic lights simply use stick figures. Rhythmic clicking or beeping is also common for pedestrians with impaired eyesight.
A camera placed near or on the traffic light is common in Europe and the U.S. It can be a red-light camera in some European countries and cities, but more often than not, it’s a speed camera that fines you automatically if you’re going above the speed limit.
Tech
Ericsson is leaving Kista for central Stockholm, in the largest office lease in Swedish history
The 71,000-square-metre Hagastaden campus, signed with Atrium Ljungberg and Castellum, ends more than two decades in the suburb once branded Sweden’s Silicon Valley.
Ericsson is moving its global headquarters out of Kista. The Swedish telecoms-equipment maker said on Monday that, starting in 2028, it will gradually relocate its Stockholm operations, including the HQ, R&D functions, group functions, and the Imagine Studio showcase space, to a new city campus in the Hagastaden district, north of central Stockholm.
The numbers attached to the move are substantial. Across new leases with Atrium Ljungberg and Castellum, plus a Castellum agreement Ericsson signed earlier for the Infinity property, the company will occupy roughly 71,000 square metres in Hagastaden across six buildings.
Atrium Ljungberg’s portion alone, three buildings totalling 58,000 square metres on a 15-year contract, is described by the landlord as the largest office lease in Swedish history and the largest known office deal in Europe so far this year.
Annual rent to Atrium Ljungberg lands at about 360m kronor ($39m) at 2026 levels.
Castellum’s new pieces, the 9,500-square-metre Emerald House and the 3,500-square-metre Jubileumshuset, carry an annual rental value of roughly 80m kronor, according to the company’s release.
That sits on top of the 24,000-square-metre Infinity contract Castellum signed previously, expected to be ready by late 2027.
Börje Ekholm, Ericsson’s chief executive, framed the move in talent terms.
“With a vibrant location in the heart of the city’s technology collaboration and innovation community, including easy access to our changing business ecosystem, partners and decision makers, Hagastaden is clearly best-placed to address our future operations,” he said in the company’s statement.
“A thriving city campus will also strengthen our attraction for the top talent of the future.”
The translation is that the Kista calculation no longer works. The suburb in northern Stockholm has spent thirty years marketing itself as Sweden’s Silicon Valley, with Ericsson’s presence as the central evidence.
That story has been deteriorating for several years. Office vacancy rates in Kista ran at 26.7% in the first quarter of 2026, more than double the central Stockholm rate, according to Colliers data cited by Bloomberg.
The facility-management firm Coor Service Management announced its own departure from Kista in late 2024, citing security concerns; reports of organised-crime activity in the surrounding area have become a recurring feature of Swedish business coverage.
Ericsson’s lease did not name those factors, but the campus calculus is unmistakable.
The deal is a clear positive for the two landlords. Atrium Ljungberg shares rose as much as 5.1% on Monday, the most since April 8, and Castellum gained 2.1%.
Pareto Securities analyst Viktor Byrenius told Bloomberg the agreements were “a sign of strength” for Atrium Ljungberg, which has been working through elevated vacancy across the Stockholm region.
The Hagastaden lease materially shifts that occupancy story for the next decade and a half.
For Ericsson, the move comes against a quieter recent set of financial prints. The company narrowly missed Q1 profit estimates in April, as the North American 5G upgrade cycle that drove 2024 and early 2025 began to unwind.
Headcount in Sweden has been declining; the company cut roughly 1,200 jobs locally last year.
The Hagastaden campus is being designed for a smaller, denser, more central operation than the sprawling Kista footprint it replaces, which is its own form of strategy statement.
Move-in is phased and slow. Ericsson said the process will begin in early 2028 and run for several years.
The Infinity building is due late 2027; the rest of the Hagastaden campus is still under construction, on a deck built above one of the city’s major highways. By the time the relocation is complete, Ericsson’s last fixed link to Kista will, in practical terms, be gone.
Tech
Battle Of The Telephoto Smartphones
On the Find X9 Ultra, the primary camera has a 200-megapixel 1/1.28-inch sensor. With a low f/1.5 aperture possible, this is an incredibly versatile camera, built to take in light and work well even in difficult shooting conditions. There’s also a pair of telephoto cameras. The first has a 200MP sensor and can zoom up to 3x (70mm equivalent) for portrait photos and general-purpose shots, while the showstopper is an ‘ultra’ telephoto, capable of 10x zoom at 50MP.
It’s rare, but we’ve seen 10x zoom in smartphones, including, briefly, Samsung’s Galaxy S23 Ultra. However, they weren’t paired with such high-resolution sensors. This offers more detail in shots, as well as the ability to digitally crop down to get even closer to the subject — although you won’t need to nearly as often. The Find X9 Ultra also has a 50MP ultra-wide camera and a 3.2MP multispectral sensor to strengthen white balance and color accuracy.
However, Oppo’s innovative 10x telephoto is the most thrilling part of the phone’s penta camera setup. The 10x optical zoom also opens up the possibility of 20x lossless zoom, all before we start attaching Oppo’s teleconvertor lens. It also has sensor-shift stabilization to improve clarity and reduce the chances of blur. (Vivo has its own solution, which we’ll get to in a minute.)
The 3x telephoto camera is a convenient midpoint between the main camera and its huge sensor and the incredible range of the 10x telephoto. However, Oppo gets a little too keen on computational photography boosting here and I’d often get shots with ghostly outlines, especially of human subjects. Overly aggressive digital sharpening also made some images look unnatural.
Within the camera app (and arguably too many shooting modes), Oppo’s collaboration with Hasselblad gives shooters a Master Mode that blissfully strips away the computational AI tricks and augmentations. This means that while you won’t get that AI nip-tuck on telephoto shots, you also won’t get nightmarish low-res faces or scrambled alien lettering. I broadly preferred it, though I occasionally missed the better low-light performance of the AI-boosted basic photo mode.
The Vivo X300 Ultra has the exact same 1/1.12-inch 200MP main camera sensor, although it has a narrow 35mm focal length, which could be argued to be more “cinematic’. Its aperture can go as low as f/1.85, losing again to its Oppo rival.
The X300 Ultra ultrawide camera, however, performs head and shoulders above the Find X9 Ultra’s version. Unlike most smartphone ultra-wide cameras, which I cynically view as a lazy effort by companies to add another camera to their smartphones, Vivo went to town. To start, Vivo added optical image stabilization (OIS), which is rare for this focal length. This, combined with a 50MP sensor, means images look crisper and more detailed than those from rival devices, which typically use lower-res sensors.
To Oppo’s credit, its ultrawide camera isn’t bad. The Find X9 Ultra also has a 50MP camera sensor and a lower f/2.0 lens. However, the sensor isn’t as big (the X300 Ultra’s 1/1.28-inch sensor is nearly twice the physical size of the Find X9 Ultra’s 1/1.95-inch sensor ) and it lacks built-in OIS. There’s also a lot less lens flaring on light sources with the Vivo phone, likely due to Zeiss’ anti-reflective lens treatment.
The X300 Ultra’s telephoto (another 200MP sensor) maxes out at 3.7x zoom without a teleconverter and while you can crop down from that for more ‘zoom’, it loses a lot of detail and adds a lot of artifacts in the process. Fortunately, for those looking to punch in further, Vivo has you covered.
Tech
Save $200 on M5 MacBook Air 15 in Amazon Memorial Day Sale
Save $200 on Apple’s 15-inch MacBook Air for Memorial Day weekend.
Amazon’s $200 discount delivers the lowest price ever on the 2026 15-inch MacBook Air with Apple’s M5 chip.
Amazon’s early Memorial Day deal knocks $200 off the standard M5 MacBook Air 15-inch laptop in your choice of Starlight or Sky Blue.
Buy 15″ MacBook Air M5 for $1,099.99
This deal delivers the lowest price we’ve seen on the new 15-inch MacBook Air that was released in March 2026. Equipped with Apple’s M5 chip with a 10-core CPU and 10-core GPU, the standard configuration also has 16GB of unified memory and 512GB of storage.
In our hands-on M5 MacBook Air review, we found that although the 2026 release is an incremental update, it’s still an excellent buy for most.
And for those wanting the extra screen real estate found in the 15-inch model, picking it up at the lowest price ever is always a plus.
If you’re looking for additional power and a larger port selection, Amazon is also knocking $250 off every 2026 16-inch MacBook Pro configuration it sells. You can read more about the sale in our deal article.
Tech
Jeff Bezos describes his $38B startup Prometheus for the first time: ‘Nothing to do with robotics’

When CNBC’s Andrew Ross Sorkin described Jeff Bezos’ startup Project Prometheus as being “really about AI robotics” in an interview on Wednesday, the Amazon founder interrupted with a correction.
“It’s a little premature for me to talk about it, but we are not — we have nothing to do with robotics,” Bezos said. He went on to offer the most detailed public description yet of the secretive startup, for which he is co-CEO: Prometheus is developing an “artificial general engineer,” he said, building next-generation tools for designing physical objects.
Bezos called it “a very, very modern version” of CAD, or computer-aided design, adding that he is “really oversimplifying here,” and reiterating that it’s premature for him to give much detail.
He said Prometheus is “something I got so excited about that I became the co-CEO of the company, putting a lot of time into it, a lot of energy into it.”
The tools Prometheus is building will “help companies like Blue immensely,” Bezos added, referring to his space venture Blue Origin. However, he said, the company “deserves its own special focus” as “its own big idea” rather than being housed inside Amazon or Blue Origin.
His comments mark a rare hint of what’s happening inside a company that has operated almost entirely in stealth since news of its formation was reported in November 2025.
Project Prometheus launched with $6.2 billion in funding, led by Bezos and Vik Bajaj, a former Google X executive. Bloomberg reported in April that the company closed a $10 billion round at a $38 billion valuation, with JPMorgan and BlackRock among the investors.
The company has hired roughly 120 employees from firms including OpenAI, DeepMind, Meta and xAI, and operates out of San Francisco, London and Zurich.
Much of the outside reporting on Prometheus has characterized it as focused on robotics and manufacturing automation, which came in part from analyzing LinkedIn profiles of its hires. Bezos’ description Wednesday as a design-tools company focused on engineering physical objects suggests a different ambition, or at least a more specific one.
Tech
Kalshi And Rhode Island Sue Each Other In Latest Challenge To Prediction Markets
Rhode Island joins other states that have taken similar legal action.
Rhode Island is the latest state to challenge prediction markets on the legality of sports betting within its jurisdiction. As reported by The Providence Journal, opposing lawsuits from the state’s attorney general, Peter Neronha, and Kalshi were filed against each other earlier this week. Neronha sued both Kalshi and Polymarket, accusing the platforms of circumventing the state’s regulations that only allows sports gambling through a singular state-sponsored platform.
However, Kalshi proactively filed its own legal action against Rhode Island arguing that its event contracts, including those predicting the outcomes of sports events, can only be regulated on a federal level by the US Commodity Futures Trading Commission (CFTC). Still, Rhode Island’s attorney general is looking for a permanent court-ordered ban that prevents Kalshi and Polymarket from offering “sports-related events contract” in the state.
“There is no substantive difference between sports betting and ‘events contract’ in this context,” Neronha said in a press release. “Kalshi and Polymarket know that, and we know that.”
While the dual lawsuits only cover the legality in Rhode Island, its eventual ruling could create a major precedent on how prediction markets operate in other states. Before Rhode Island’s lawsuit, Nevada and New Jersey also sent cease-and-desist letters to prediction market platforms, only to end up in similar legal battles. More recently, Minnesota passed a bill that includes a ban on prediction markets operating in the state, which will likely be contested by the CFTC.
Tech
It’s Like the Olympics – But Steroids Are Allowed
“Think Olympics on steroids. Literally,” quips the BBC, describing Sunday’s controversial Enhanced Games event in Las Vegas featuring dozens of athletes “using performance-enhancing drugs to try and break world records in track, weightlifting and swimming.
Some $25m (£18.6m) in prize money is up for grabs — with cash prizes for winners… The drugs they use must be legal, and approved by the Federal Drug Administration. But substances like testosterone and human growth hormone — banned by the World Anti-Doping Agency — are not only celebrated here, they’re encouraged and for sale…
Health experts warn that anabolic steroids and growth hormones can cause strokes and cardiovascular damage, among other risks. Event organisers claim Enhanced will push the limits of human performance while critics, especially in the Olympic movement, dismiss it as an affront to the spirit and founding principles of competitive sport…
Earlier this month, the Enhanced Group — the company behind the competition — began trading on the New York Stock Exchange. And the competition is seemingly being treated as an opportunity for Enhanced to sell performance-enhancing medicine and supplements online.
“The project was founded by entrepreneurs Aron D’Souza and Maximilian Martin in 2023,” the artidcle points out, “and has attracted backing from prominent investors including billionaire Peter Thiel and Donald Trump Jr.”
And NPR adds that “Most of the participating athletes trained for the competition in Abu Dhabi, as part of Enhanced’s own study.”
Enhanced did not break down what specific athletes used which drugs, but they announced on Wednesday in the lead-up to the event that 91% of the athletes competing used testosterone or testosterone esters, 79% used human growth hormone, and 62% used stimulants, such as adderall…
The games have been largely panned by outside medical experts and sports governing bodies. Multiple recent studies assess the harm surrounding the Enhanced Games. Travis Tygart, the CEO of the U.S. Anti-Doping Agency, called the games a “dangerous clown show that puts profit over principle” in a statement. The International Olympic Committee said the games are a “betrayal of everything that we stand for.” The World Anti-Doping Agency (WADA) last year urged U.S. authorities to stop the games. The International Federation of Sports Medicine said in 2024 that they see the medical oversight as “insufficient” to support the
athletes.
Tech
Samsung’s next foldable phones could get a confusing name swap
Samsung is getting ready to launch two new foldable phones in July, and if a recent leak is accurate, the company is about to flip its naming convention completely, and it’s going to confuse a lot of people.
Tipster Ice Universe has claimed on Weibo that the phone we have been calling the Galaxy Z Fold 8 Wide will actually launch simply as the Galaxy Z Fold 8. The device we expected to be the standard Galaxy Z Fold 8 will instead become the Galaxy Z Fold 8 Ultra.

While I can see why Samsung is considering the new naming scheme, there’s no denying it’s going to cause a whole lot of confusion.
Does the name change actually make sense?
I don’t think so. Yes, the wider Galaxy Z Fold 8 Wide is supposedly packing only dual rear cameras and a 4,800mAh battery, and the regular Fold 8 (which will be renamed to Ultra) will pack a triple rear camera system and a bigger battery. So on paper, the better-specced device getting the Ultra name is logical enough.
But the problem is that anyone who has followed the Galaxy Z Fold lineup will walk into a store expecting the Galaxy Z Fold 8 to be a direct successor to the Galaxy Z Fold 7. Instead, they are getting a wider, passport-style device that is a completely different form factor. That is not an upgrade; that is a different product wearing a familiar name.

Samsung is essentially asking buyers to unlearn years of brand familiarity, and that rarely goes smoothly. Many people will be confused at the point of purchase, and that confusion could easily cost Samsung sales.
Is the Galaxy Z Fold 8 Ultra worth the name?
The Ultra name carries serious expectations, and Samsung better deliver. Rumors only suggest a small spec bump with better cameras and a bigger battery. In fact, leaks suggest that the Galaxy Z Fold 8 will miss out on a number of new features, so Samsung will have to surprise us with something extraordinary to earn the Ultra moniker.
Tech
Under-trained techie didn’t claim overtime for mistakenly failing to phone it in
Networks
After making a medical clinic’s network rather ill, she ‘kept working until I somewhat knew what I was doing’
WHO, ME? Welcome once again to “Who, Me?” –
The Register’s Monday column in which we celebrate the
things you get wrong at work, and your skill at emerging unscathed.
This week, meet a reader we’ll
Regomize as “April,” who told us that early in her career, she worked for a
company that operated several medical clinics.
April admitted she did not feel
she was a great candidate for the job as she had recently completed her CompTIA
A+ certification – one of the most entry-level certs – and had only tangential experience
supporting doctors as they struggled to use a single application.
That résumé was enough to score a
job imaging new PCs, deploying them, and handling whatever other tasks popped up.
“One day I received a task to
convert an unused space into offices, so I loaded an armload of PCs and a dozen VoIP
phones into my car and drove the 45 minutes to the clinic,” April wrote.
“The deployment went
smoothly – or so I thought – because at each of the desks one of the people who
knew what they were doing had already put two network drops, one for the phone
and one for the PC.”
April was therefore able to
methodically get through the job, then slow down to tackle the slightly tricky
elements.
“Some of the desks needed two
computers,” she wrote. “On those, I was expected to use the secondary Ethernet
port on the phones to get internet to those PCs.”
April hooked everything up with time
to spare and decided to put her feet up for the 15 minutes that remained until 5pm – meaning she would glide into an unusually early end to her working day.
“My paid respite was interrupted
quickly by a nurse who found me and let me know none of the computers in the
entire clinic could access the internet,” April wrote.
“I wasn’t trusted with any tasks
that could actually break anything, so I was convinced that something major had
happened like a fiber line getting cut, or an outage with our ISP,” she told
Who, Me?
She investigated anyway and found
pings produced no results, so in a panic called head office and hoped
colleagues hadn’t already left for the day.
“I spent maybe an hour running
around frantically searching for anything with one of my superiors giving me
commands over the phone until someone who knew what they were doing could get
to the site and take a look in person,” she wrote.
That person eventually arrived and
quickly spotted the problem: April had made a single mistake by plugging both of
one phone’s Ethernet ports into the network, which disrupted every other
connection.
“They unplugged one and everything
came back up almost instantaneously,” she confessed. “I was genuinely surprised
they weren’t absolutely furious. They just clapped me on the back and said: ‘Well,
you won’t do that again.’”
April was so upset by her mistake
that she amended her timesheet to record that she finished work at 5pm. “If
anyone deserved an hour and a half of OT, it wasn’t me,” she wrote, adding that
she soon took it upon herself to acquire a networking certification at her own
expense.
“I kept working there for a few
more years until I became one of the people who at least somewhat knew what
they were doing,” she said.
Have you been asked to
tackle a task you weren’t properly trained to complete? Or been hired without
all the necessary skills? In either case, feel free to demonstrate your
storytelling competence by clicking here to share your tale with Who, Me? Let’s shine a light on the shoddy bosses who dumped
you into these messes! ®
Tech
Uber goes after Delivery Hero in full, with an offer that sits below the close
The €33-per-share proposal lands at a slight discount to Friday’s price, but with Uber already sitting on a quarter of the company and DoorDash circling, the bid is the start of the negotiation, not the end of it.
Delivery Hero confirmed on Saturday that Uber has tabled a formal takeover offer for the Berlin-based food-delivery group, at €33 a share.
The price is, awkwardly for Uber, a 1.76% discount to where Delivery Hero closed on Friday, and it arrives roughly a month after Uber almost tripled its stake in the company to 19.5%, with another 5.6% held through derivatives. On any reasonable measure, this is the opening bid.
The numbers, according to the company’s statement, are an indicative proposal of €33 per share to all shareholders. The Financial Times put the implied price tag at about $11bn (€10bn). Uber’s chief executive Dara Khosrowshahi flew to meet Delivery Hero’s supervisory board chair Kristin Skogen Lund in person before the bid was filed, the FT reported.
Delivery Hero, for its part, said only that it remains “fully focused” on the strategic review already underway and declined to disclose further terms.
The strategic review is the reason any of this is happening on this timeline. Several of Delivery Hero’s largest shareholders have been pressing for it for months, and chief executive Niklas Östberg, who co-founded the company in 2011, announced last week that he would step down once a successor is in place.
The succession is targeted for the end of 2026, no later than March 31, 2027. The board has appointed advisors and opened the process; Uber has now put a number on the table inside it.
It is not the only number. DoorDash, sources told the FT, has explored a full takeover of its own and has separately expressed interest in Delivery Hero’s Middle Eastern business, Talabat.
Some shareholders have been arguing for a price closer to €40 a share. The combination of a slight-discount offer, a sitting blockholder, a parallel competing approach, and an ongoing succession review is the structural setup of a deal that gets renegotiated in public over the next several weeks.
For Uber, the logic for going hostile-adjacent is straightforward. Delivery Hero operates in more than 60 countries across Europe, the Middle East, Asia, Africa, and Latin America, through brands including Foodpanda, Glovo, Talabat, and South Korea’s Baedal Minjok.
It is the largest non-US food-delivery footprint in the world and, with DoorDash already absorbing Deliveroo last year and Just Eat Takeaway having sold to Prosus for $4.3bn, it is also the last one of scale that has not been claimed.
A full acquisition would give Uber Eats a delivery network across the markets where DoorDash now competes most directly with it.
Uber’s capital allocation in 2026 has otherwise been pointed elsewhere. The company has committed roughly $10bn to its robotaxi programme, including a $1.25bn investment in Rivian for a fleet of up to 50,000 autonomous R2 vehicles, alongside partnerships with Wayve, Nissan, Lucid, Nuro and MOIA.
Khosrowshahi has framed the strategy, in successive earnings calls, as building “everyday utility” across mobility, delivery, and commerce.
Q1 2026 results showed gross bookings up 25% year on year and autonomous trips up tenfold. Bolting Delivery Hero onto the delivery leg fits the framing.
Whether it fits at €33 is the open question. Uber shares slipped 1.6% on Friday after Bloomberg first reported the talks. The 1.76% discount to Delivery Hero’s Friday close gives investors arguing for €40 a clear rhetorical wedge, and gives the German board cover to ask for more.
Tech
Lab of UW Nobel winner cracks challenge of creating roomier protein cages to deliver genetic medicines

Medical experts use gene therapies for a variety of ailments — treating hemophilia with a clotting-factor gene or dosing a cancer patient with therapeutic DNA or RNA.
But doctors need a means of delivering that curative gene to a target in a patient’s body. Their solution has been harnessing viruses to shuttle the material, but the treatments are very expensive, limited in how much genetic material can be delivered and can trigger negative reactions.
Now researchers in the lab of Nobel laureate David Baker at the University of Washington’s Institute for Protein Design have created a way to build virus-like protein cages that could one day serve as delivery capsules for life-saving payloads.
Two strategies for engineering the protein cages are described in back-to-back papers published today in the journal Nature.
The discoveries open new possibilities for designing proteins from scratch, said Shunzhi Wang, a former Baker Lab postdoctoral scholar. He is now an assistant professor at New York University’s Grossman School of Medicine. Wang was a lead author on the papers, joined by Sangmin Lee, David Chemielewsk, Baker and others.
To visualize the new protein cages, imagine a soccer ball, which is built from pentagons and hexagons in a repeating pattern described as “quasisymmetry” because the subunits are identical but have different neighbors.

Scientists could previously make symmetrical protein cages from one or two types of building blocks, but that limited their overall size. During a casual Friday afternoon conversation, Wang, Lee and Baker hatched the idea of mixing building blocks by swapping partners from previous protein configurations.
“It was actually a serendipitous discovery,” Wang said.
The process didn’t go smoothly at first with proteins often assembling into globs. But by accounting for different geometric features and running many experiments, the scientists developed instructions that produced proteins with a curvature. As those curved proteins came together, they sensed a more crowded environment and responded by forming a mix of pentagons and hexagons to create a roomier configuration.
The resulting quasisymmetrical cages were two to three times larger than those formed by a single shape, bringing the scientists closer to the complex designs found in naturally occurring viral structures and making space for larger genetic payloads.
“These papers show that protein design is beginning to capture some of the architectural principles that nature uses to build at very large scales,” Baker said in a statement.
Additional studies are needed before the protein cages would be ready for human research and treatments. That includes tests of their immunogenicity — the immune response they might trigger if the body perceives them as dangerous invaders.
Farther down the line, Wang envisions the structures operating like a computer motherboard on which essential, modular components can be layered. In this case, that could include adding binding sites for directing the protein cage to a specific cellular target.
“That’s the beauty of this,” he said. “We can make tailored capsules for building and making more precise genetic medicines.”
The Nature papers are titled: “Design of one-component quasisymmetric protein nanocages” and “De novo design of quasisymmetric two-component protein cages.” Institutions leading the research were the IPD, NYU’s Langone Health, and South Korea’s Pohang University of Science and Technology. Collaborators included the Holt Lab at NYU’s Grossman School of Medicine, and the DiMaio and Veesler labs at the UW.
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